Protein Kinase Cδ Is Essential to Maintain CIITA Gene Expression in B Cells
نویسندگان
چکیده
منابع مشابه
B-cell Signaling: Protein Kinase Cδ Puts the Brakes on
Protein kinase C (PKC) is one of the cell’s most important signal-transducing molecules, responding to a diversity of extracellular cues to regulate a number of central processes, including proliferation, metabolism, migration and death [1]. It is also one of the more complex signal transducers, constituting a family of serine/threonine kinases that can phosphorylate a multitude of cellular sub...
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OBJECTIVE CD4+ T cells from patients with active lupus have impaired ERK pathway signaling that decreases DNA methyltransferase expression, resulting in DNA demethylation, overexpression of immune genes, and autoimmunity. The ERK pathway defect is due to impaired phosphorylation of T(505) in the protein kinase Cδ (PKCδ) activation loop. However, the mechanisms that prevent PKCδ T(505) phospho...
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Protein kinase Cδ (PKCδ), an isoform of PKC, has been shown to act as a critical mediator of tumor progression and apoptosis; however, its role in musculoskeletal tumors is still unknown. In the current study, we examined the expression of PKCδ in human musculoskeletal tumor tissue samples, and investigated the effects of siRNA downregulation of PKCδ on human malignant fibrous histiocytoma (MFH...
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Protein kinase Cδ (PKCδ) deficiency causes autoimmune pathology in humans and mice and is crucial for the maintenance of B cell homeostasis. However, the mechanisms underlying autoimmune disease in PKCδ deficiency remain poorly defined. Here, we address the antigen-dependent and -independent roles of PKCδ in B cell development, repertoire selection, and antigen responsiveness. We demonstrate th...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2006
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.177.2.950